The COMBINE Trial
What is the trial about?
Type 2 diabetes is more common and is diagnosed at an earlier age in South Asian adults. This is worrying because diabetes can cause heart, kidney and physical function problems.
The aim of this trial is to see whether combining structured exercise and a high protein, low energy diet can minimise muscle loss while attempting to reverse diabetes. We will also look at whether blood sugar control is improved over 12 weeks.
Who can take part?
People from the South Asian community
Living with type 2 diabetes
Aged between 40 – 65 years old
Body mass index (BMI) between 27 and 45
What does the trial involve?
Past studies have shown that low energy diets lead up to half of people reversing their type 2 diabetes. This means that blood sugar levels return to normal. This is called ‘diabetes remission.’ A low energy diet means eating a lot less than normal for a short period of time. Once people have lost enough weight, they can start to eat regular food again.
Structured exercise, such as walking and simple weight training activities, can also improve blood sugar levels and strengthen muscle. The effect of combining the two approaches - low energy diet and structured exercise - have not been studied together in terms of reversing diabetes or preserving muscle.
There is no control group, all eligible participants will receive the diet intervention.
To find out more and to take part:
Please fill in the form below or contact the study team:
Tel: 0116 258 4312